THE MAP — WHERE THEY LIVE
CN III — OCULOMOTOR MOTOR +PARA
What it does: ALL eye muscles EXCEPT lateral rectus (VI) and superior oblique (IV). Plus: levator palpebrae (eyelid) + parasympathetic pupil constriction.
Memory: CN III does everything. VI and IV are the exceptions. LR₆SO₄ — Lateral Rectus = VI, Superior Oblique = IV, rest = III.
SURGICAL (Compressive) — CN III
Pupil affected FIRST
→ Parasympathetic fibers run on the OUTSIDE of the nerve
→ Compression hits outer fibers first
Causes: Aneurysm (PComm), uncal herniation, tumor
⚠️ Dilated pupil = EMERGENCY
MEDICAL (Ischaemic) — CN III
Pupil SPARED
→ Ischaemia hits the INSIDE (vasa nervorum)
→ Outer parasympathetic fibers still get blood from outside
Causes: Diabetes, hypertension, vasculitis
Painful but pupil is normal
Compression → roof passenger falls first → pupil dilates (surgical = emergency)
Ischaemia → engine fails inside → pupil spared (medical = diabetes)
CN V — TRIGEMINAL MIXED
Three divisions — one image:
Motor component: V3 ONLY — muscles of mastication (masseter, temporalis, pterygoids). "V3 = jaw power."
Key clinical tests:
• Corneal reflex: Afferent = V1 (ophthalmic), Efferent = VII (facial). Lost in Wallenberg (spinal V nucleus hit).
• Jaw jerk: V3. Brisk = UMN lesion above pons (pseudobulbar palsy).
• Trigeminal neuralgia: Electric shock pain in V2/V3 distribution. India: carbamazepine first-line.
Only V3 has motor. Think: you need your jaw (V3) to chew = motor.
CN VII — FACIAL MIXED
THE most tested CN distinction in medicine:
UMN LESION (Stroke)
Forehead SPARED ✓
Only lower face weak (contralateral)
→ Upper face gets bilateral cortical supply
→ One cortex gone? Other still feeds forehead.
Look for: associated arm/leg weakness
LMN LESION (Bell's Palsy)
ENTIRE half face paralyzed
Forehead INCLUDED — can't raise eyebrow
→ The nerve itself is damaged below the nucleus
→ No alternate supply possible
Look for: hyperacusis, loss of taste ant 2/3, dry eye
Bell's palsy extras: Most common CN mononeuropathy. Viral (HSV-1). Steroids within 72h. India: must rule out Hansen's disease (leprosy) — thickened nerve, patch near ear.
Stroke = Superior (UMN) = Spares forehead.
CN IX (Glossopharyngeal) + X (Vagus) MIXED +PARA
Why together: They travel together through jugular foramen, share nucleus ambiguus, and are tested together clinically.
Division of labor:
• IX: Sensation posterior 1/3 tongue + taste post 1/3 + afferent gag reflex + carotid sinus/body
• X: Motor to palate, pharynx, larynx (recurrent laryngeal nerve) + efferent gag + parasympathetic to thorax/abdomen to splenic flexure
Bedside test — "say AAH":
Unilateral X lesion → uvula deviates AWAY from lesion (weak side can't pull) → palate drags toward normal side.
Recurrent laryngeal nerve (branch of X):
Left RLN loops under aortic arch — longer course — more vulnerable.
Causes of left RLN palsy: aortic aneurysm, mitral stenosis (large LA), lung cancer (L hilum), post-thyroidectomy
→ Hoarseness of voice. India: think thyroid surgery complication first.
Tongue (XII) → deviates TO lesion. Uvula (X) → deviates AWAY from lesion.
Left RLN = "Left loops Low" (under aortic arch) = Left is more vulnerable.
CN XII — HYPOGLOSSAL MOTOR
Pure motor to tongue.
LMN Lesion (nucleus/nerve)
Tongue deviates TO the lesion
→ Weak side can't push, strong side pushes tongue toward weak
+ Ipsilateral atrophy + fasciculations
Seen in: Dejerine, tumors, MND
UMN Lesion (cortex/tract)
Tongue deviates AWAY from lesion
→ CST crosses → cortical damage affects opposite genioglossus
No atrophy, no fasciculations
Seen in: Stroke (with hemiplegia)
UMN tongue: Away from cortical lesion (fibers cross).
Bulbar vs Pseudobulbar:
Bulbar (LMN — IX,X,XII nuclei) = fasciculations, wasting, quiet nasal speech, absent jaw jerk
Pseudobulbar (UMN — bilateral cortex) = spastic tongue, brisk jaw jerk, emotional lability (pathological crying/laughing)
⚠️ DIRECTION RULES — YOUR KNOWN TRAP
| Structure | LMN lesion → deviates | UMN lesion → deviates | Anchor |
|---|---|---|---|
| Tongue (XII) | TO lesion | AWAY from lesion | LMN "licks its wound" |
| Uvula (X) | AWAY from lesion (both UMN & LMN) | Dragged by strong side | |
| Face (VII) | Entire half (LMN) | Lower half only (UMN) | Bell's = Both halves |
5 RETENTION ANCHORS
- CN III pupil: outside = surgical (dilated, emergency), inside = medical (spared, diabetes). Passenger on roof of bus falls first when bus is crushed.
- CN VII: Bell's = Below = Both halves. Stroke = Superior = Spares forehead. This one distinction earns 2 marks alone.
- Tongue TO the lesion (LMN), Uvula AWAY from lesion. They are OPPOSITES. Tongue licks its wound. Uvula is dragged by the strong side.
- Left RLN loops low under aortic arch. Left vocal cord palsy → think aortic aneurysm, mitral stenosis, lung cancer, thyroid surgery.
- Corneal reflex: V1 in, VII out. Lost in Wallenberg (V nucleus hit). Tests two nerves in one — examiners love it.