PI Exam — Slot Architecture Dashboard

01 · NUTRITION / VITAMIN

P=1.00 17/27 known · 5/5 sessions ▼

BOUNDARY: Is a dietary substrate (vitamin, mineral, macronutrient, dietary pattern) the primary subject?

89% novelty → expect a vitamin/mineral never asked in PI. Wildcard pool is your insurance.

GRADED (8)

B12 7.5 B6+INH 7.5 Vitamin D 8.5 Vitamin A 7.5 Vitamin K 8 Iron/Heme 7 TPN 8.5 Refeeding Syndrome 8.5

COVERED — NOT GRADED (5)

Vitamin C Nutritional Neuropathy 7 Malabsorption Tests Thiamine/B1 (Blueprint) Vitamin E (Minimal)

SUPPRESSED (2)

B3/Niacin ×0.10 (Sep25) B9/Folate ×0.25 (Jan25)

KNOWN GAPS — HIGH/MEDIUM (5)

Mediterranean Diet Iodine Zinc PEM (Kwashiorkor/Marasmus) Obesity/BMI

KNOWN GAPS — LOW (7)

Selenium Chromium Omega-3/6 Enteral Nutrition ICMR RDA/Fluorosis Copper (nutrition angle) Manganese

WILDCARD — NEVER LISTED, CURRICULUM-VALID (10)

Biotin (carboxylase, egg white injury) Carnitine (fatty acid shuttle, dialysis) Choline (neural tube, fatty liver) Molybdenum (sulfite oxidase) Fluoride (fluorosis belt, India) Nutrition in CKD (phosphate binders) Nutrition in Pregnancy (ICMR) Nutrition in Critical Illness Microbiome–Nutrition Axis Vitamin Toxicity (A, D, E, K)

02 · ANATOMY / PHYSIOLOGY

P=1.00 5/9 known · 5/5 sessions ▼

BOUNDARY: Does the answer require spatial/structural/functional anatomy knowledge or a diagram?

89% novelty → any body structure is a candidate. Diagram questions favor this slot.

GRADED (2)

Cardiac Conduction 6.5 Nephron/Renal Physiology 7.5

COVERED (3)

Coronary Circulation Spinal Cord Tracts Portal System (Partial)

SUPPRESSED (2)

Cerebral Circulation ×0.10 (Sep25) Temperature Regulation ×0.10 (Sep25)

KNOWN GAPS (2)

Neuroanatomy — Functional Localization GI Arterial Supply

WILDCARD (12)

Brachial Plexus Circle of Willis (standalone) Cavernous Sinus Cranial Nerves (diagram) Lymphatic System / Thoracic Duct Liver Segments (Couinaud) Bronchopulmonary Segments Thyroid/Parathyroid Anatomy Adrenal Gland Zones Autonomic Nervous System Dermatomes CSF Circulation/Ventricles

03 · PHARMACOLOGY

P=1.00 6/10 known · 5/5 sessions ▼

BOUNDARY: Is a drug name or drug class the primary subject?

GRADED (2)

ACE Inhibitors Strong Metformin 7

COVERED (4)

ARNi (Sacubitril-Valsartan) SGLT2 Inhibitors Diuretics (embedded in nephron) Spironolactone (embedded)

SUPPRESSED (2)

Antiarrhythmics ×0.10 (Sep25) Bedaquiline ×0.25 (Jan25)

KNOWN GAPS (3)

Anticonvulsants Immunosuppressants Newer Anti-TB (Delamanid)

WILDCARD (14)

Monoclonal Antibodies (-mab/-nib) DOACs (vs Warfarin, reversal) Biologics (TNF-α, IL-6) Opioid Pharmacology Antifungals (Azoles, AmB) Insulin Types (rapid→degludec) Antiplatelet Agents (P2Y12) Statins (pleiotropic, myopathy) Corticosteroid Pharmacology CYP450 / Drug Interactions Beta-Blockers CCBs (DHP vs Non-DHP) Aminoglycosides Pharmacokinetics (Vd, CL, t½)

04 · PATHOPHYSIOLOGY

P=0.80 4/8 known · 3/5 sessions ▼

BOUNDARY: Is the answer about HOW a disease process works at cellular/molecular level (not management)?

GRADED (2)

Septic Shock (PI angle) 8 Uric Acid Metabolism 6.5

COVERED (3)

Atherosclerosis RAAS Pathophysiology DM Pathophysiology (unconfirmed)

KNOWN GAPS (3)

Bilirubin Metabolism Hepatic Encephalopathy Thyroid Pathophysiology

KNOWN GAPS — LOW (1)

Heme Synthesis / Porphyria

WILDCARD (8)

Hemostasis Cascade Complement System Apoptosis vs Necrosis Amyloidosis (pathogenesis) Shock — Cardiogenic vs Distributive Pulmonary Hypertension Mechanism Autoimmunity (tolerance breakdown) Tumor Immunology / Immune Evasion

05 · PARASITOLOGY / LIFECYCLE

P=0.75 5/8 known · 3/5 sessions ▼

BOUNDARY: Does the answer require lifecycle/organism biology knowledge?

COVERED (HTML LIFECYCLES) (5)

Strongyloides (hyperinfection) Leishmania Wuchereria Schistosoma DIMAOE Framework

SUPPRESSED (2)

Echinococcus ×0.25 (Jan25) Taenia Solium ×0.10 (Sep25)

LOW PRIORITY (1)

Plasmodium (2022, ×0.10)

WILDCARD (10)

Ascaris lumbricoides Hookworm (Ancylostoma/Necator) Trichuris trichiura Toxoplasma gondii Entamoeba histolytica Giardia lamblia Cryptosporidium Dracunculus (guinea worm) Trichinella spiralis Cysticercosis (NCC — Indian context)

06 · ELECTROLYTE

P=0.50 5/6 known · 2/5 sessions ▼

BOUNDARY: Is a specific ion (K⁺, Na⁺, Ca²⁺, Mg²⁺, PO₄³⁻) the primary subject?

GRADED (4)

Hypokalemia 7 Hyperkalemia 7 Calcium Metabolism 7 →Nutr,Pathophys Metabolic Alkalosis 8 →Acid-Base

COVERED (2)

Hyponatremia / SIADH Drug-Induced Dyselectrolytemia

GAPS (1)

Magnesium (standalone)

WILDCARD (5)

Phosphate Disorders Hypernatremia Hypercalcemia (malignancy) Hypokalemia vs Bartter vs Gitelman Electrolytes in CKD

07 · ACID-BASE

P=0.50 3/5 known · 2/5 sessions ▼

BOUNDARY: Does the answer require Henderson-Hasselbalch, anion gap math, or pH/buffer reasoning?

COVERED (3)

HAGMA (ungraded) RTA Types 1, 2, 4 Euglycemic DKA (embedded)

GAPS (2)

Respiratory Acid-Base Mixed Disorders

WILDCARD (5)

Normal Anion Gap Metabolic Acidosis (NAGMA) Lactic Acidosis (Type A vs B) ABG Interpretation (systematic) Urinary Anion Gap Acid-Base in CKD

08 · INVESTIGATION

P=0.60 1/5 known · 3/5 sessions ▼

BOUNDARY: Is the answer about THE TEST itself (how it works, interpretation) — not the disease?

COVERED (1)

PFTs (HTML drill, untested)

SUPPRESSED (1)

CBNAAT ×0.25 (Jan25)

GAPS (3)

Bone Marrow Studies LN Biopsy Flow Cytometry

WILDCARD (10)

Immunofluorescence (direct/indirect) ELISA / Western Blot PCR / RT-PCR Serum Protein Electrophoresis Autoantibody Panel Interpretation HLA Typing Tumor Markers Echocardiography (technique) Urinalysis (systematic) Pleural Fluid Analysis (Light's)

09 · POISONING

P=0.40 1/7 known · 2/5 sessions ▼

BOUNDARY: Is a toxin/poison the primary subject?

GRADED (1)

OP Poisoning 6.5

EMBEDDED (1)

Lithium Toxicity (NDI mechanism)

SUPPRESSED (1)

Paracetamol ×0.10 (Sep25)

GAPS (3)

Snake Venom (coastal Karnataka) Copper / Wilson's Disease Scorpion Sting

WILDCARD (8)

Methanol / Ethylene Glycol Carbon Monoxide Cyanide Lead Poisoning Arsenic Mercury Mushroom Poisoning (Amanita) Oleander / Plant Poisoning (India)

10 · GENETICS / PROGRAMME PSEUDO-SLOT

P=0.20-0.30 1/6 known · 1/5 sessions ▼

⚠ NO FORMAL BOUNDARY TEST — catch-all for topics failing all 9 tests above. Fails recurrence criterion (1/5). Treat as low-probability junk drawer.

COVERED (1)

Gene Therapy (ungraded)

SUPPRESSED (2)

Biomedical Waste ×0.10 (Sep25) NACP ×0.10 (Sep25)

GAPS (3)

Clinical Trials Pharmacogenomics Hypersensitivity Reactions

WILDCARD (6)

CRISPR/Gene Editing Stem Cell Therapy National Health Mission Bioethics (consent, DNR) Precision Medicine CAR-T Cell Therapy

#	Topic	Grade	Source	Status	Paper
22	Stroke — Acute Ischemic, First 24h, Mimics, Secondary Prevention	—	Tracker	✅ Complete	PII
23	Lupus Nephritis (PII angle)	—	Tracker	✅ Complete	PII
24	SLE — Diagnosis & Therapeutics	—	ChatGPT	✅ Ladder soft	PII
25	HIV-associated Tuberculosis	—	Tracker	✅ Complete	PII
26	Henoch-Schönlein Purpura / IgA Vasculitis	—	Tracker	✅ Complete	PII
27	Vasculitis Classification	—	Tracker	✅ Complete	PII
28	Guillain-Barré Syndrome	—	Tracker	✅ Complete	PII
29	Osteoporosis	—	Tracker	✅ Complete	PII
30	Hypersensitivity Pneumonitis / Eosinophilic Pneumonia	—	Tracker	✅ Complete	PII
31	Congestive Heart Failure (PI/PII)	—	Tracker	✅ Complete	PII
32	Heart Failure — HFrEF	—	Tracker	✅ Complete	PIII
33	Heart Failure — HFpEF	—	Tracker	✅ Complete	PIII
34	Acute Pancreatitis	—	Tracker	✅ Complete	PIII
35	Autoimmune Hepatitis	—	Tracker	✅ Complete	PIII
36	Lupus Nephritis (PIII angle)	—	Tracker	✅ Complete	PIII
37	ILD / DPLD	—	Tracker	✅ Complete	PIII
38	Inflammatory Myopathies	—	Tracker	✅ Complete	PIII
39	Paraneoplastic Syndromes	—	Tracker	✅ Complete	PIII
40	Subclinical Atherosclerosis	—	Tracker	✅ Complete	PIII
41	AKI	—	Tracker	✅ Complete	PIII
42	Tropical Sprue	—	Tracker	✅ Complete	PIII
43	IBS	—	Tracker	✅ Complete	PIII
44	Septic Shock — Therapeutic Strategies (PIII)	—	Tracker	✅ Complete	PIII
45	Short Bowel Syndrome	—	Tracker	✅ Complete	PIII
46	ADA 2023 Diabetes Mellitus	—	Tracker	✅ Complete	PIV
47	AUC / Clinical Trials	—	Tracker	✅ Complete	PIV
48	ESC 2022 Hypertension	—	Tracker	✅ Complete	PIV
49	Bempedoic Acid	—	Tracker	✅ Complete	PIV
50	Nintedanib	—	Tracker	✅ Complete	PIV
51	Chikungunya Arthritis	—	Tracker	✅ Complete	PIV
52	Dementia	—	Tracker	✅ Complete	PIV
53	Hypertensive Emergencies	—	Tracker	✅ Complete	PIV
54	Carcinoid Syndrome	—	Tracker	✅ Complete	PIV
55	Mucormycosis (I,II,III,IV)	—	Tracker	✅ Complete	Cross
56	Systemic Sclerosis	8/10	ChatGPT	✅ Graded	Cross
57	Metabolic Alkalosis	8/10	ChatGPT	✅ Graded	Cross
58	Genetics / Pharmacogenomics Blueprint	—	Claude	✅ Blueprint v2	Cross
59	Calcium Metabolism	7/10	Claude	✅ Graded	Cross
60	Rheumatoid Arthritis	—	ChatGPT	⚠️ Partial	Unclear
61	Antiphospholipid Syndrome	—	ChatGPT	⚠️ Partial	Unclear
62	Cardiomyopathies	—	ChatGPT	⚠️ Partial	Unclear
63	Bilirubin Metabolism	—	ChatGPT	⚠️ Partial	Unclear

Pattern	Example	Fix
Direction Inversions	Conn's K⁺ direction, DCT Ca²⁺, V2 mechanism	Describe FUNCTION first, then state direction
Opposite Substitution	Mumps↔measles, parafollicular↔chief, ROMK↔"RMPK4"	If 50/50 unsure → describe function, skip name
Tail Mark Drops	Forgets treatment para, Indian context, modern concepts	"Did I cover: treatment? Indian? What's new?"
Over-Elaboration	"Hydralation" when correct = "hydrazone"	Describe function if unsure of term
Cross-Contamination	Using Term A vocabulary in Topic B	Keep terminology siloed during recall